Rid yourself of uncomfortable fungal conditions and feel free and confident in soft, smooth, healthy skin. Retrieved 20 June 2023.Effective Athlete’s Foot, Jock Itch, Ringworm Cream: Our antifungal balm is a clinically proven fungal infection and jock itch treatment. Archived from the original on 7 February 2007. ^ "Kodak Chemicals: Q-LAB Process Control Handbook: Publication Z-6".Archived from the original on 15 July 2007. ^ "Kodak Chemicals: Process E-6 Publication: Z-119"."A comparison of three crystalline forms of miconazole: solvent-free, ethanol monosolvate and hemihydrate". ^ Kaspiaruk H, Chęcińska L (June 2022).^ US 5461068, Thaler I, Strauss R, "Imidazole derivative tincture and method of manufacture", issued 24 October 1995, assigned to Current Assignee Corwood Laboratories Inc and Bausch Health Companies Inc."Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor". ^ Duret C, Daujat-Chavanieu M, Pascussi JM, Pichard-Garcia L, Balaguer P, Fabre JM, et al."Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens". ^ a b British National Formulary '45' March 2003.Vienna: Österreichischer Apothekerverlag. World Health Organization model list of essential medicines: 21st list 2019. Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition.
Archived from the original on 21 September 2022.
MICONAZOLE NITRATE 2 ANTIFUNGAL CREAM SKIN
Pharmacokinetics Īfter application to the skin, miconazole can be measured in the skin for up to four days, but less than 1% is absorbed into the bloodstream. In addition to its antifungal actions, miconazole, similarly to ketoconazole, is known to act as an antagonist of the glucocorticoid receptor. Miconazole inhibits the fungal enzyme 14α-sterol demethylase, resulting in a reduced production of ergosterol. sulfonamides with a potential to cause hypoglycaemia (low blood sugar).drugs that also prolong the QT interval because of potential problems with the heart rhythm.Miconazole is contraindicated for people who use certain drugs that are metabolized by CYP3A4, for the reasons mentioned above: These interactions are not relevant for miconazole that is applied to the skin. Such interactions occur for example with anticoagulants of the warfarin type, phenytoin, some newer atypical antipsychotics, ciclosporin, and most statins used to treat hypercholesterolemia. This can lead to increased concentrations of drugs that are metabolized by the liver enzymes CYP3A4 and CYP2C9, because miconazole inhibits these enzymes. Miconazole is partly absorbed in the intestinal tract when used orally, as with the oral gel, and possibly when used vaginally. The oral gel can cause dry mouth, nausea and an unpleasant taste in about 1–10% of people.
Internal application is used for oral candidiasis or vaginal thrush ( yeast infection). Miconazole is used externally for the treatment of ringworm, jock itch, and athlete's foot. It is on the World Health Organization's List of Essential Medicines. Miconazole was patented in 1968 and approved for medical use in 1971. It works by decreasing the ability of fungi to make ergosterol, an important part of their cell membrane. Miconazole is in the imidazole family of medications. Use in pregnancy is believed to be safe for the baby. Ĭommon side effects include itchiness or irritation of the area in which it was applied. It is applied to the skin or vagina as a cream or ointment. It is used for ring worm of the body, groin (jock itch), and feet (athlete's foot). Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina.
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